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- 专家介绍
张卫国(骨科)
- 所属科室:
- 外科学
- 职称:
- 主任医师
- 出诊时间:
- 专家介绍:
- 二级教授、主任医师,博士生导师,大连医科大学附属第一医院党委书记,国务院特殊津贴专家,辽宁省特聘教授,辽宁省优秀专家,中国预防医学会骨与关节专业委员会常委,中华医学会辽宁省骨科分会副主任委员,日本广岛大学访问学者。
主要研究方向为骨关节退行性疾病、关节运动损伤,尤其是关节软骨损伤、软骨组织工程修复领域的临床、基础研究。近年来主持软骨损伤相关国家课题2项,辽宁省课题3项,荣获辽宁省科技进步奖一等奖1项、二等奖4项,三等奖1项,大连市科技进步一等奖1项、二等奖1项;发表学术论文40余篇,SCI收录22篇。从医执教30年,指导培养硕士生50余人,博士研究生12人。
研究方向:
骨关节退行性疾病、关节运动损伤
关节软骨损伤及软骨组织工程修复
在研项目:
1.国家自然科学基金(面上项目)No.81371706
微流控芯片调控的双相应力作用下-软骨细胞/仿生化取向支架复合体生物学特性及其软骨组织工程的实验研究
70万 2014.1-2017.12 项目负责人
2.国家自然科学基金(面上项目)No.81171464
壳聚糖复合FK506轴突导向神经鞘管研制及促进神经修复后再生的实验研究
58万 2012.1-2015.12 项目负责人
3.No.LR2011026
关节镜下骨髓间充质干细胞、软骨细胞移植治疗关节软骨缺损
10万 2011.11-2014.12项目负责人
4.辽宁省高峰医学项目 No.20101607
干细胞与软骨细胞移植治疗关节软骨与半月板损伤的转化医学研究No.20101607, 50万 2010.1-2012.12项目主持人
文章发表(近5年):
1.Biomimetic poly/polycaprolactone blend scaffolds for cartilage tissue engineering. Journal of Materials Science: Materials in Medicine. (2019) 30:53.
IF=2.467通讯作者
2.Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway. Int J Mol Sci. 2017 May 4;18(5).
IF=3.226通讯作者
3.Long non-coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR-335-5p in osteosarcoma cells. Cancer Sci. 2017 May;108(5):859-867. Epub 2017 May 19.
IF=3.974通讯作者
4.Extracellular matrix characteristics of co-cultured zonal chondrocytes and bone marrow mesenchymal stem cells. Int J Clin Exp Pathol,2017, (10,2) 984-995
IF=1.581 通讯作者
5.Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. Cancer Lett. 2016 Nov 28;382(2):137-146
IF 5.992通讯作者
6.Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut-off values of postoperative plasma D-dimer levels. Exp Ther Med. 2016 May;11(5):1716-1720. Epub 2016 Mar 2.
IF 1.28通讯作者
7.Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3. Sci Rep. 2015 Oct 13,5,15101. srep15101.
IF 5.578通讯作者
8.Microfluidics‑based optimization of neuroleukin‑mediated regulation of articular chondrocyte proliferation,Molecular Medicine Reports, 2015, 13(1):67-74.
IF 1.554通讯作者
9.Effects of Incorporating Carboxymethyl Chitosan into PMMA Bone Cement Containing Methotrexate. PLoS One. 2015 Dec 14;10(12):e0144407.
IF 3.234通讯作者
10.Risk factors for deep vein thrombosis after orthopedic surgery and the diagnostic value of D-dimer. Ann Vasc Surg. 2015;29(4):675-81.
IF 1.045通讯作者
11.An integrated microfluidic device for screening the effective concentration of locally applied tacrolimus for peripheral nerve regeneration,Experimental & Therapeutic Medicine, 2015, 9(9):154-158.
IF 1.269通讯作者
12.FK506-loaded chitosan conduit promotes the regeneration of injured sciatic nerves in the rat through the upregulation of brain-derived neurotrophic factor and TrkB. Journal of the Neurological Sciences,2014, (334) 20-26
IF=2.262 通讯作者
招生专业:
外科学(骨关节方向)