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柳杨
- 所属科室:
- 基础相关学科
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- 研究员
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- 专家介绍:
- 于2006年在澳大利亚墨尔本大学获得理学(药理)学士学位。2011年于澳大利亚莫纳什大学(Baker国际心脏病研究所)取得医学博士学位,主要以血小板为研究对象,研究血小板在心脏炎症和纤维化等方面的调控机制。2012年归国后就职于大连医科大学(肿瘤干细胞研究院),主要研究血小板在肿瘤微环境中促进肿瘤细胞转移的调控机制,并主持国家自然科学(青年)基金一项。2015年柳杨就职于大连医科大学附属第一医院(心血管疾病研究所),主要研究方向为药物致心肌损伤的分子机制。目前以第一/通讯作者(含共同)身份发表SCI文章15篇(包括hypertension、 ATVB等1区心血管专业期刊)。 主持课题 辽宁省教育厅,基础科研项目,LZ201917,血小板来源的TGF-β1促进心房纤维化的机制研究,2019-01至2021-12; 大连医科大学附属第一医院,科技英才资助项目,2017YC003,SDF-1/CXCR4通路活化的循环纤维细胞在房颤心房纤维化中的作用及机制研究,2017-01至2019-12; 辽宁省人社厅,203219,血小板激活乳腺癌细胞Hippo-Yap 通路进而促进癌细胞转移的机制研究,2014-01至2016-12; 国家自然科学基金委员会,青年基金项目,81201656,血小板上调乳腺癌细胞膜整合素的表达进而促进癌细胞转移的分子机制研究,2013-01至2015-12。 发表第一/通讯作者文章 1. Tan R, Cong T, Xu G, Hao Z, Liao J, Xie Y, Lin Y, Yang X, Li Q, Liu Y, Xia YL. Anthracycline-induced atrial structural and electrical remodeling characterizes early cardiotoxicity and contributes to atrial conductive instability and dysfunction. Antioxidants and Redox Signaling. (并列通讯作者) 2. Hao Z, Lv H, Tan R, Yang X, Liu Y, Xia YL. A Three-Dimensional Microfluidic Device for Monitoring Cancer and Chemotherapy-Associated Platelet Activation. ACS Omega 2021;6(4):3164-3172. (并列通讯作者) 3. Liu Y, Lv H, Tan R, An X, Niu XH, Liu YJ, Yang X, Yin X, Xia YL. Platelets Promote Ang II (Angiotensin II)-Induced Atrial Fibrillation by Releasing TGF-beta1 (Transforming Growth Factor-beta1) and Interacting With Fibroblasts. Hypertension 2020;76(6):1856-1867.(第一作者) 4. Lv H, Tan R, Liao J, Hao Z, Yang X, Liu Y, Xia Y. Doxorubicin contributes to thrombus formation and vascular injury by interfering with platelet function. Am J Physiol Heart Circ Physiol 2020;319(1):H133-H143.(并列通讯作者) 5. Niu XH, Xie YP, Yang S, Chen Y, Xu L, Zhang Y, Liu Y. IL-18/IL-18R1 promotes circulating fibrocyte differentiation in the aging population. Inflamm Res 2020;69(5):497-507.(并列通讯作者) 6. Li X, Gu J, Zhang Y, Feng S, Huang X, Jiang Y, Xia Y, Liu Y, Yang X. l-arginine alleviates doxorubicin-induced endothelium-dependent dysfunction by promoting nitric oxide generation and inhibiting apoptosis. Toxicology 2019;423:105-111.(并列通讯作者) 7. Huang X, Liu Y, Yang X, Lai S, Zhang Y, Gu J, Li H, Xie Y, Xia Y. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci 2019;227:94-100.(并列第一作者) 8. Yang X, Gu J, Lv H, Li H, Cheng Y, Liu Y, Jiang Y. Uric acid induced inflammatory responses in endothelial cells via up-regulating(pro)renin receptor. Biomed Pharmacother 2019;109:1163-1170.(并列通讯作者) 9. An X, Jiang G, Cheng C, Lv Z, Liu Y, Wang F. Inhibition of Platelets by Clopidogrel Suppressed Ang II-Induced Vascular Inflammation, Oxidative Stress, and Remodeling. J Am Heart Assoc 2018;7(21):e009600.(并列通讯作者) 10. Liu Y, Niu XH, Yin X, Liu YJ, Han C, Yang J, Huang X, Yu X, Gao L, Yang YZ, Xia YL, Li HH. Elevated Circulating Fibrocytes Is a Marker of Left Atrial Fibrosis and Recurrence of Persistent Atrial Fibrillation. J Am Heart Assoc 2018;7(6).(第一兼通讯作者) 11. Gao XM, Moore XL, Liu Y, Wang XY, Han LP, Su Y, Tsai A, Xu Q, Zhang M, Lambert GW, Kiriazis H, Gao W, Dart AM, Du XJ. Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction. Clin Sci (Lond) 2016;130(13):1089-104.(并列第一作者) 12. Zhang R, Guo H, Xu J, Li B, Liu YJ, Cheng C, Zhou C, Zhao Y, Liu Y. Activated platelets inhibit hepatocellular carcinoma cell differentiation and promote tumor progression via platelet-tumor cell binding. Oncotarget 2016;7(37):60609-60622. 13. Gao XM, Liu Y, White D, Su Y, Drew BG, Bruce CR, Kiriazis H, Xu Q, Jennings N, Bobik A, Febbraio MA, Kingwell BA, Bucala R, Fingerle-Rowson G, Dart AM, Morand EF, Du XJ. Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation. J Mol Cell Cardiol 2011;50(6):991-9.(并列第一作者) 14. Liu Y, Gao XM, Fang L, Jennings NL, Su Y, Q X, Samson AL, Kiriazis H, Wang XF, Shan L, Sturgeon SA, Medcalf RL, Jackson SP, Dart AM, Du XJ. Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction. Arterioscler Thromb Vasc Biol 2011;31(4):834-41.(第一作者) 15. Liu Y, Ibrahim AS, Tay BH, Richardson SJ, Bell J, Walker TI, Brenner S, Venkatesh B, Danks JA. Parathyroid hormone gene family in a cartilaginous fish, the elephant shark (Callorhinchus milii). J Bone Miner Res 2010;25(12):2613-23.(第一作者)