大连医科大学附属第一医院
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李汇华

李汇华
所属科室：
基础相关学科
职称：
教授
出诊时间：
专家介绍：
1998年获得中国协和医科大学博士学位，1998-2005年分别在美国Wake Forest大学和美国北卡大学做博士后和研究助理，2005-至今分别在北京协和医学院、首都医科大学及大连医科大学任教授，博士生导师。近些年获得享受国务院政府特殊津贴等荣誉称号。 长期从事心血管疾病发生的病理生理机制研究，从分子细胞生物学、动物模型及临床病人探讨泛素修饰、免疫炎症及营养素等在心血管疾病（包括高血压、心衰、心肌梗死及房颤等）中的作用及其分子机制。在国际心血管期刊European Heart journal（IF：23.239）、Circulation（IF：23.054）等发表SCI论文130余篇，其中通讯或第一作者（共同）论文90余篇，最高单篇他引409次。主持基金委重点项目、973计划10余个基金项目。担任10余个国内外等杂志的编委或审稿人。 研究方向：心血管疾病（包括心肌梗死、心衰、高血压、房颤等）发生发展的病理生理机制研究。 在研项目：1.2017.01-2021.12: 国家自然科学基金重点项目: 趋化因子/受体信号通路调控心力衰竭发病机制和干预的研究。10篇代表论著（*通讯或共同通讯）： 1．Lei Wang#, Yun-Long Zhang#, Qiu-Yue Lin, Yu Liu, Xu-Min, Xiao-Lei Ma, Yun-Long Xia, Jie Du*, Hui-Hua Li*. CXCL1-CXCR2 Axis Mediates Angiotensin II-induced Cardiac Hypertrophic Remodeling through Regulation of Monocyte Infiltration. European Heart Journal. 2018; 39(20):1818-1831. (IF=23.239). 2．Lei Wang, Xue-Chen Zhao, Wei Cui, Yong-Qiang Ma, Hua-Liang Ren, Xin Zhou, Yan-Zong Yang, Yun-Long Xia*, Jie Du, Hui-Hua Li*. Genetic and pharmacologic inhibition of the chemokine receptor CXCR2 prevents experimental hypertension and vascular dysfunction. Circulation. 2016; September 134(18):1353–1368. (IF=23.054) 3．Xin Xie, Hai-Lian Bi, Song Lai, Yun-Long Zhang, Nan Li, Hua-Jun Cao, Ling Han, Hong-Xia Wang* and Hui-Hua Li*. The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation. Science Advances 2019; May, 5 : eaau0495.（IF=12.804） 4．Bokang Qiao, Jing-Jun Nie, Yihui Shao, Yulin Li, Congcong Zhang, Wenjing Hao, Sijin Li, Dafu Chen, Bingran Yu, Hui-Hua Li*, Fu-Jian Xu* and Jie Du*. Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function. Small 2019, 1905925. (IF=10.856) 5．Hai-Lian Bi, Xiao-Li Zhang, Yun-Long Zhang, Xin Xie, Yun-Long Xia, Jie Du and Hui-Hua Li*. The Deubiquitinase UCHL1 Positively Regulates Cardiac Hypertrophy and dysfunction via Stabilizing EGFR Protein. Science Advances. 接受 2020. (IF=12.804) 6．Hong-Xia Wang*, Wen-Jun Li, Cui-Liu Hou, Song Lai, Yun-Long Zhang, Cui Tian, Hui Yang, Jie Du, and Hui-Hua Li*. CD1d-dependent natural killer T cells attenuate angiotensin II-induced cardiac remodelling via IL-10 signalling in mice. Cardiovascular Research. 2019 Jan 1;115(1):83-93. (IF=7.014). 7．Yun-Peng Xie, Song Lai, Qiu-Yue Lin, Xin Xie, Jia-Wei Liao, Hong-Xia Wang, Cui Tian, Hui-Hua Li*. CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy. Theranostics 2018; 8(21): 5995-6007. (IF=8.063) 8．Chen Chen, Lin-Xin Zou, Qiu-Yue Lin, Xiao Yan, Hai-Lian Bi, Xin Xie, Shuai Wang, Qing-Shan Wang, Yun-Long, Yun-Long Zhang*, Hui-Hua Li*. Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload. Redox Biology. 2019; January 20:390–401. (IF=7.793) 9．Jing Li, Shuai Wang, Yun-Long Zhang, Jie Bai, Qiu-Yue Lin, Peng Qu, Rui-Sheng Liu, Xiao-Hong Yu* and Hui-Hua Li*. Immunoproteasome Subunit β5i Promotes Ang II (Angiotensin II)–Induced Atrial Fibrillation by Targeting ATRAP (Ang II Type I Receptor–Associated Protein) Degradation in Mice. Hypertension. 2019;73:92–101.（IF=7.017） 10．Hui-Hua Li*, Monte S. Willis, Pamela Lockyer, Nathaniel Miller, Holly McDonough, David J. Glass and Cam Patterson*. Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. J. Clinical Investigation. 2007;117(11): 3211–3223.（IF=12.282） 招生专业：病理学与病理生理学（心血管疾病）
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